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Currently in the UK, injectable GLP-1 receptor agonists such as semaglutide (Ozempic) and dulaglutide (Trulicity) are well-established treatments recommended by NICE (NG28) for specific indications in type 2 diabetes management, with some formulations also approved for weight management

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Clearly, distinct sequence and structural features of tirzepatide and peptide 20 allow them to exert combinatorial agonism at two or more receptors at the same time thereby maximize the benefit of polypharmacology and minimize the limitation of mono-targeting

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