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A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in the Treatment of Cholestatic Pruritus in Patients With Primary Sclerosing Cholangitis (2024)

doi: 10.1007/s00210-024-03539-0 62 WonCSOberliesNHPaineMF

It promotes angiogenesis through VEGF pathway activation, modulates nitric oxide production, and produces cytoprotective effects in connective tissue, vascular endothelium, and gastrointestinal epithelium

10.3389/fcdhc.2022.889248 96

Hence, further research is required to establish the glucose-independent benefits of alogliptin on other organ systems for better translation of its effects and repurposing of the drug in other diseases