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References Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L et al (2018) Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome

In real-world practice, patients who experience severe gastrointestinal side effects may adjust their behavior more freely, drinking more fluids, reducing doses, or taking breaks

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Alternative escalation schedules Not everyone follows the exact 4-week protocol