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Curcumin may upregulate glutathione synthesis enzymes through activation of the Nrf2 antioxidant response element pathway (Balogun et al., 2003)

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While it has not been conclusively established whether this dysfunction is a cause or consequence of the pathological processes, growing evidence suggests that reduced proteasomal activity may contribute to the accumulation of toxic protein aggregates and the progression of neurodegeneration

Cycle length REDEFINE trials ran 68 weeks

At 25 mg/mL, the single 50 mg vial contains enough for the full 30-day cycle at both dose levels