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Biochemical and preclinical investigations suggest that AOD 9604 affects pathways involved in cellular energy regulation, including cyclic AMP signaling and downstream kinase activation
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In addition, LipRSV treatment was associated with reduced BDNF and NGF levels, further indicating that redox modulation was not paralleled by neurotrophin restoration.Together, these results suggest limited therapeutic benefit of the formulation under the experimental conditions tested and highlight the complexity of linking redox modulation to functional behavioral outcomes in ASD models
Wiener-Megnazi Z, Vardi L, Lissak A, Shnizer S, Zeev Reznick A, Ishai D, Lahav-Baratz S, Shiloh H, Koifman M, Dirnfeld M: Oxidative stress indices in follicular fluid as measured by the thermochemiluminescence assay correlate with outcome parameters in in vitro fertilization
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