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DOI: Published: Publisher Name: Springer, Singapore Print ISBN: 978-981-95-7796-5 Online ISBN: 978-981-95-7797-2 eBook Packages: MedicineMedicine (R0)

In the case of compound 2-bound structure, the N-terminal -helix of ECD penetrated to the TMD core and formed extensive contacts with residues in TM1-3, ECL1 and ECL2, resulting in an ECD-TMD interacting surface area of 1438.4 2 , similar to other small molecule agonists

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