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Future directions include the need for well-designed RCTs with large sample sizes to confirm findings, assessment of long-term safety and tolerability in patients with HS, and further research into the molecular mechanisms by which GLP-1 RAs affect HS pathophysiology
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GLP-1 side effects: what to expect and how to manage
The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal
