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doi: 10.1007/s00223-018-0395-3

10.1002/14651858.CD000016 Cochrane Database Syst

Histamine intolerance is considered a subset of MCAS where too much histamine is released from mast cells, too much histamine is taken in by consuming histamine-containing foods, histamine is not broken down in the gut because of DAO gut enzyme deficiency, or not broken down in the liver because of HNMT deficiency