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IGF-1 levels (a downstream marker of growth hormone activity) also increased by 1.5-3 times

GLP-1 release is triggered when nutrientsparticularly carbohydrates, fats, and proteinscome into contact with L-cells in the intestine

In addition, it may also interact with other drugs that affect growth hormon secretion or metabolism, such as insulin, glucocorticoids, etc

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Based on limited human pharmacology data, ipamorelin appears relatively selective, with less pronounced effects on cortisol and prolactin secretion compared with some other GH secretagogues though this selectivity has not been extensively validated in large human trials