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Food and Drug Administration (FDA) warns that consuming more than 4,000 mg per day leads to acute liver failure, with severe cases requiring liver transplantation

While not currently on the WADA list of banned substances (Wada-ama.org 2018), due to what some individuals would term as the synthetic nature of BPC 157, there may be issues associated with the use of this peptide, as seen by some sport organisations

Microglia are thought to present a cell protective anti-inflammatory phenotype in early stages of the disease, however, due to the chronic nature of PD they tend to switch to an activated pro-inflammatory subtype at latter stages of disease progression (Tang and Le, 2016)