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Interestingly, the GLP-1 receptor agonist, dulaglutide, and the dual GLP-1 and GIP receptor agonist, tirzepatide, are both characterized by a strong delayed gastric emptying upon a single dose administration, but the effect tends to subside as gastric emptying tachyphylaxis is observed after several weeks of treatment
Limiting high-fat foods, which slow gastric emptying further, can help
The extended-release formulation of metformin produces significantly fewer GI symptoms than the immediate-release version
Although their exact mechanism for cardiovascular improvement is unknown, the anti-inflammatory effects are believed to have a role
Key points: GLP-1 receptor agonists may protect the heart, kidneys and liver beyond their effects on weight loss
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