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Regarding skin lesions, bullous pemphigoid, a rare autoimmune skin disease, was found to be associated with the use of DPP-4 inhibitors in a retrospective analysis of more than 9,000 patients treated in Japan during the years 20092017

Very Large Volumes of Water at Meals Contrary to popular advice, drinking large volumes of water with meals on a GLP-1 can worsen nausea by adding to gastric distension

In a double-blind study of n=16 chronic insomniac patients, intravenous DSIP at 25 nmol/kg over 3 nights was associated with higher sleep efficiency and shorter sleep latency (the time it takes to fall asleep) compared with placebo, but the effects were described as weak [4]

Injection-related irritation: The needle and injection process can temporarily irritate the skin