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6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia
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This allows peripheral inflammatory cytokines to infiltrate the central nervous system, triggering the activation of microglia (the brains resident immune cells)
Sermorelin mimics natural GHRH while ipamorelin activates the ghrelin receptor, so combining them can amplify growth hormone release
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