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Tissue-specific expression in our analysis highlights the paraventricular nucleus (PVN) and area postrema (AP) as key targets of weight-reducing medications, which impact neural circuits regulating energy balance and eating behaviors

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The protocol is administered as subcutaneous injections over a 4-week or 8-week cycle

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The new 2026 framework codifies how you can use in silico modeling, organ-on-a-chip, and human cell-based systems as primary evidence to bypass traditional animal study bottlenecks