However, despite their effectiveness, weight loss responses to single-agent GLP-1RAs may plateau over time, reflecting adaptive physiological mechanisms that counteract sustained energy deficit
Although both are GLP-1 drugs, liraglutide is about half as effective as the 2.4-mg dose of semaglutide (Wegovy), Garvey says
So whats actually going on, and which changes are worth paying attention to
If you have persistently high glucose levels (above 15 mmol/L), positive ketones, vomiting, or drowsiness, seek same-day urgent care via NHS 111 or attend A&E if severely unwell
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