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Gastro-Intestinal Side Effects and Discontinuation Real-world data covering 200,000 patients show 42% reporting at least one gastrointestinal event within three months of therapy initiation, with 15% discontinuation by year one

[1] Capsimax adds a second, independent appetite-suppressing effect through capsaicin's action on satiety signaling

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Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements