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Moreover, the multidrug and toxin extrusion proteins (MATEs) are crucial in the transportation of metformin (Jensen et al., 2016)

GLP-1 receptor activation also inhibits beta cell apoptosis

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Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the receptor every GLP-1 compound binds), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (tied to glucose handling and GLP-1 secretion) describe the metabolic terrain a clinician prescribes into