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The GSH concentration declines slowly over the 48 hour period to about 50% of normal and the rate of GSH export declines to 67% of normal consistent with the experiments reported in [33]
This is the central reason the GLOW protocol works: it supports multiple bottlenecks simultaneously
GHK-Cu appears to reset this decline by upregulating the transcription factors that drive fibroblast proliferation
In Synechocystis , exposure to gentamicin stimulated GSH synthesis, whereas a gshB mutant was killed by the drug, despite carrying a resistance gene
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