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At the end of the experiment, the whole fish in each tank were anthesthetized on ice, and sampled to collect liver, muscle and visceral for molecular and biochemical indexes

GIP is not known to interact with the peripheral autonomic nervous system, but its appetite inhibiting effect in rodents requires interaction with cerebral GIPR [92]

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Furthermore, one third of participants treated with semaglutide lost at least 20% of baseline weight, a reduction approaching that reported 1 to 3 years after bariatric surgery, particularly sleeve gastrectomy (approximately 20 to 30% weight loss)