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Here is a breakdown of the primary benefits and the challenges patients may face: Advantages: Significant Weight Loss: Clinical trials show 1520% body weight reduction

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Quality and extent of evidence Key limitations and criticisms Balanced assessment For EPP, the evidence base is moderatetostrong: two highquality RCTs demonstrate clinically meaningful gains in sunlight tolerance and QoL, corroborated by prospective cohorts and PASS data with generally mild adverse events