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It is characterized by several symptoms such as depressed mood, hopelessness about the future, and thoughts of dying or suicide (World Health Organization, 2023a,b)

Treatment with NR and PTER is effective and safe and therefore it could be a promising therapeutic strategy in ALS, due to its action on the pathogenesis of this disease

However, Brain Health is in Decline An estimated 6.2 million Americans age 65 and older are living with Alzheimer's dementia in 2021

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Recent uses of lipid nanoparticles, cell-penetrating and bioactive peptides for the development of brain-targeted nanomedicines against neurodegenerative disorders