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Potential strategies include restoring mitochondrial quality control, improving NAD + -sirtuin signaling, redirecting glycolysis and anaplerosis, normalizing BCAA catabolism, modulating ketone metabolism, correcting lipotoxicity, and reducing ferroptosis (27, 28, 30, 4547, 49, 51, 59, 64)
Cohen JF, Ward KM, Gittleman J, Perez E, Pia T, Shuter J, et al
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The analysis revealed that both the comproportionation and triad models were better suited to represent the experimental data than the reduced model, but were inconclusive with respect to overall model selection, given that both AIC/BIC values were extremely similar (Fig
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