While some people notice improvements in skin hydration and texture within 2-4 weeks, more significant changes in firmness, elasticity, and overall appearance typically become apparent after 8-12 weeks of consistent use
Adv Biol Reg
Some uncommon side effects that could occur are some weakness, nausea, bowel problems, dizziness, lethargy, weight loss, thirst, nervous irritability, itchy skin, frequent urination, high levels of calcium
doi: 10.1016/s0950-3536(05)80216-1 Pubmed Abstract CrossRef Google Scholar View reference in article 67 BottiglieriTHylandKReynoldsEH
Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational first-in-human trial