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Mechanistically, this relationship is driven by chronic low-grade inflammation, insulin resistance, increased levels of insulin and IGF-1, elevated estrogen and adipokines such as leptin, and impaired immune surveillance, all of which contribute to tumor initiation, proliferation, and evasion of apoptosis [144]
These numbers represent the highest weight loss ever achieved with any medication in a large-scale clinical trial
10.1038/s41580-020-00317-7 16 CantiniG.MannucciE.LuconiM
doi:10.1097/01.JAA.0000533660.86287.04 Teas J, Baldeon ME, Chiriboga DE, Davis JR, Sarries AJ, Braverman LE
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