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(accessed June 2022) 17Overweight and obesity management NICE guideline [NG246]

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For molecules excluded from oral development, this review has surveyed realistic alternatives that deserve systematic consideration: pulmonary delivery for rapid-onset needs, nasal delivery for rescue applications, buccal/sublingual delivery for potent peptides accommodating variability, and most importantly, long-acting injectables, depots, implants, and pumps that often outperform oral approaches on pharmacokinetic predictability and total cost

Statements Author contributions All authors have contributed to the review of the topic and to the writing of the review

Not a long-term protocol