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Because of its long activity window and potent effects, improper use can create significant risks
A more descriptive approach is recommended and can be qualified by lesion distribution or use of subclassification and discretionary qualifiers (Figure 71 )
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Notably, endogenous GHK-Cu levels in human plasma are age-dependent, dropping from ~200 ng/mL at age 20 to below 80 ng/mL after age 60
It receives raw materials and has to synthesise GSH from scratch, which is an energy-dependent process limited by cysteine availability and the rate-limiting enzyme gamma-glutamylcysteine synthetase
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