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doi:10.1017/S1368980016002603

Dihexa is a research peptide and is not FDA-approved for human use

Whether this reflects a shift from GHD1 to GDH2 isoform [28] is not known but, if so, this pushing effect of reduced pH effect could be additive with the above pulling effect of a reduced TCA pool (Figure 2)

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Hence, in order to reproduce in vitro an effect observed in vivo obtained after several weeks of treatment, it appears to be necessary to increase the drug concentrations for in vitro determination