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Based on this knowledge, Met has emerged as a significant commodity in the global economy (Neubauer and Landecker, 2021)
What they do report is a cascade of positive effects that lead to a more optimized physiological state overall
Overweight individuals with T2DM should reduce energy intake while maintaining a balanced diet rich in nutrient-dense foods like fruits, vegetables, whole grains, lean proteins, and healthy fats, limiting added sugars, sodium, and saturated fats [148]
Although substantial weight loss can reduce pathological joint loading and systemic inflammation, the direct pharmacological effects on synovial fibroblastsattenuating their inflammatory signalling and fibrotic activation may offer an additional, disease-modifying and analgesic mechanism that targets the local synovial environment, driving pain and structural progression
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