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There is growing evidence that the microbiome may be critical for establishing, maintaining, and reversing obesity 14,15,16 , and that both diet composition and adiposity each contribute to modulation of the mouse gut microbiome profile 49
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Research published in Nature demonstrated that NNMT inhibition in white adipose tissue (WAT) shifts cellular metabolism toward fat oxidation and thermogenesis, mimicking aspects of caloric restriction without dietary intervention
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