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Particles can come from: Degraded peptide forming insoluble aggregates Contamination during manufacturing or storage Rubber stopper fragments from repeated needle punctures Crystallization of dissolved components If you see particles, do not try to filter them out

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Its two distinguishing features are: The central proline imposes backbone rigidity through its cyclic side chain The lysine provides a positive charge and the valine a hydrophobic side chain, giving the peptide an amphipathic character There is no coordination chemistry and no redox-active center

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