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Reactions don't improve with continued use

Physiology of incretins in health and disease

Signs Your Dose May Need Adjustment Signs Your Dose May Be Too Low No improvement in sleep quality after 3-4 weeks Minimal energy changes after 6-8 weeks Lab work shows IGF-1 levels unchanged from baseline Signs Your Dose May Be Too High Water retention (puffy hands, ankles, face) Tingling or numbness in extremities Joint stiffness or discomfort Headaches, particularly in the morning Carpal tunnel-like symptoms If you experience these symptoms, contact your provider

Sherrie Singh-Bryan: Eating balanced, small portions, staying hydrated, and getting adequate exercise are all nonmedical interventions that help improve side effects

The UK MHRA issued a public advisory in November 2008 that MT-II is an unlicensed medicine and supply is illegal under the Medicines Act 1968, triggered by 18 adverse-event reports detailing 74 separate reactions