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A meta-analysis of global birth prevalence of spina bifida showed that when mandatory fortification was compared to countries with voluntary fortification or no fortification program, there was a 30% reduction in live births with spina bifida, [36] with some countries reporting a greater than 50% reduction

Seuring T, Archangelidi O, Suhrcke M

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Theyre FDA approved for different uses

The T[SH] 2 molecules deliver reducing equivalents to peroxidases and other enzymes responsible for neutralizing ROS, and the oxidized form of trypanothione is reduced by trypanothione reductase (TryR) in presence of NADPH produced by the pentose phosphate pathway (PPP) (discussed below and reviewed in Irigon et al., 2008)