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The next-generation GLP-1 drugs pipeline is also relevant context

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Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

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Additionally, treatment with NRF2 activators in PINK1- or PARKIN-deficient drosophila restored mitochondrial function, elevated mitophagy rates and suppressed oxidative stress (Gumeni et al., 2021)