In obesity, abnormal adipose metabolism transports large amounts of free fatty acids to the liver, increasing hepatic fat synthesis, decreasing fat breakdown, and ultimately causing hepatic steatosis
doi:10.1016/j.drudis.2021.07.009
Link Novel tricyclic small-molecule inhibitors of nicotinamide N-methyltransferase for the treatment of metabolic disorders
NNMT inhibition via 5-Amino-1MQ was associated with higher NAD+ levels, thereby influencing sirtuin activation and mitochondrial function
Traditional obesity intervention strategies (e.g., dietary control, exercise, conventional weightloss drugs) are often limited by slow onset, obvious side effects, and high rebound rates, and can hardly fundamentally reverse the abnormal metabolic phenotype of adipose tissue