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Moderate caloric restriction (15-20% below maintenance) supports AOD-9604 protocols without triggering metabolic adaptation or excessive muscle loss

GLP-1 Receptor Agonist Exenatide Attenuates the Detrimental Effects of a High-Fat Diet on Sperm Function in Mice

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Translating Results to Pounds For men at various starting weights, using the 15% average: Starting at 220 pounds: Average expected loss: 33 pounds End weight: 187 pounds High responder (20%+): Could reach 176 pounds or lower Starting at 250 pounds: Average expected loss: 37-38 pounds End weight: 212-213 pounds High responder: Could reach 200 pounds or lower Starting at 280 pounds: Average expected loss: 42 pounds End weight: 238 pounds High responder: Could reach 224 pounds or lower Starting at 300 pounds: Average expected loss: 45 pounds End weight: 255 pounds High responder: Could reach 240 pounds or lower These are approximations based on average results

Fujii et al., 2012) giving rise to different responses depending on the stimulated receptor (Pedersen et al., 2018)