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Dosing Common Side Effects Storage & Administration Dosing Common Side Effects Storage & Administration Start your patients with once-daily RYBELSUS Successfully start your patient's dosing journey Successfully start your patients on their journey to improve glycemic control with 7 mg and 14 mg 1 Help your patients with T2D reach their optimal therapeutic dose Gradual dose escalation designed to help your patients adjust to therapy 1 Establish clear expectations from the start Make sure your patient is well-prepared for how to take RYBELSUS in order for it to work as intended

Medical Evaluation Before Starting GLP-1 Therapy Before beginning semaglutide, PlexusDx patients with pancreatitis history undergo careful review: recent pancreatic imaging (ultrasound, CT, or MRI), pancreatic enzyme levels (amylase, lipase), triglyceride panel, and documentation of pancreatitis cause and severity

declared that compromised insulin signalling causes amyloid peptide accumulation in the brain [25, 46]