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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig
Finally, we discuss how individual variation arises and its consequences for one-carbon and glutathione metabolism
To emphasize the importance of these aberrations in ASD, this disorder is now referred to as developmental synaptopathy [63]
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