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If you have been diagnosed with type 2 diabetes, your eligibility for GLP-1 medications is essentially guaranteed regardless of BMI, because these drugs were originally developed and approved for diabetes management
Genomic Regulation: It resets the gene expression of the Ubiquitin-Proteasome System (UPS), enhancing the cell's ability to clear toxic proteins (upregulating 41 UPS genes)
On a different level, GLP-1RAs reduce the concentration of angiotensin II (Ang II), which lowers arterial hypertension in T2DM and improves systemic insulin sensitivity ( 4.3 Gastrointestinal effects The gastrointestinal (GI) tract is greatly impacted by GLP-1RAs
Every body responds differently
Upper gastrointestinal bleeding typically presents as melaena rather than bright red rectal bleeding, though brisk upper GI bleeding can occasionally present as haematochezia
