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Additional pathways implicated in tubulointerstitial injury and renal fibrosis include TNF- and tissue inhibitor of metalloproteinase mRNA-1, which facilitate fibrosis by preventing the breakdown of collagen (93)

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Despite advances in treatment over the last 50 years, obesity and T2D continue to be rapidly growing drivers of morbidity and mortality in the 21st century

Impairment of lipid emulsion metabolism associated with carnitine insufficiency in premature infants

Key Industry Developments In August 2025 , research from Rockefeller University identified mitochondrial glutathione as a critical metabolite enabling breast cancer metastasis, with elevated levels in metastatic cells facilitating survival in new tissues through signaling mechanisms rather than antioxidant activity