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Only if response is still inadequate does the article say a provider reassessment, potentially including biomarker evaluation, should weigh a different single agent rather than a combination
That leaves the airway unprotected at a time when the patients cough reflex is impeded
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The requirements include patients at high metabolic or cardiovascular risk with a BMI greater than 27 with prediabetes or established cardiovascular disease, or a BMI over 30 with uncontrolled hypertension despite treatment, advanced kidney disease, or heart failure
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