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This once daily tablet uses an absorption enhancer to allow the semaglutide peptide to reach systemic circulation intact

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While tirzepatide does not require dose adjustment for renal impairment, gastrointestinal side effects (nausea, vomiting, diarrhea) could potentially lead to dehydration and acute kidney injury, particularly in patients taking renally excreted beta blockers like atenolol

This underscores the importance of early detection and intervention