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Rather than adding an insulin secretagogue that might cause weight gain, adding Retatrutide addresses both issues simultaneously

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A combined effect bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] What else are studies showing on GLP-1 RAs: A number of studies are now showing positive effects from GLP-1 that are independent of weight loss

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Phase 3 trial results released in December 2025 showed participants lost an average of 28.7% of their body weight (about 71 pounds) over 68 weeks, the highest weight loss reported for any obesity medication to date