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Twelve+ Phase 3 trials, three FDA approvals, a published CVOT in 13,165 patients, and a mature prescribing-information safety envelope

Individual factors also play a significant role in determining who experiences bloating and to what degree

Nitric oxide is synthesized by nitric oxide synthases (NOS) and plays vital roles in vascular regulation, neurotransmission, and immune responses [5, 30]

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