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Red flags that mean call the provider During a prednisone course on Zepbound, these symptoms warrant a same-day call to your provider: Fasting glucose above 250 mg/dL Post-meal glucose above 300 mg/dL Excessive thirst plus frequent urination plus blurred vision (classic hyperglycemia symptoms) Severe nausea or vomiting that prevents you from taking medications or fluids Confusion or unusual fatigue Severe abdominal pain, especially radiating to the back (possible pancreatitis, a known GLP-1 risk) Black or tarry stools (possible steroid-related GI bleeding) Severe mood changes including suicidal thoughts (rare but documented with high-dose steroids) Most prednisone bursts don't trigger any of these