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Nielsen SA et al
CD003158, DOI:10.1002/14651858.CD003158, PMID 12804452.
In some CoVs, the N-terminal domain (NTD) of the S1 subunit can be used for receptor binding (such as in mouse hepatitis virus) or might also be involved in virus attachment to host cells by recognizing specific sugar molecules (such as in TGEV, BCoV and IBV) or has an important role in the pre-fusion to post-fusion transition of the S protein 49,50,51
The 16-Week Extended Protocol: For goals that take a bit longer to manifest, like significant changes in tissue quality or deeper metabolic shifts, a 16-week cycle is common
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