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Thus, glutathione depletion triggers death consistent with ferroptosis in BT-549 cells and identifies lipid hydroperoxides as the lethal ROS species underlying glutathione addiction in these cells

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doi: 10.1038/s41583-019-0132-6 66 ThapaACarrollN

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If it cant protect it, then B12 gets damaged, and it cant activate the cells as it should