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Greer 2007) that the US Food and Drug Administration (FDA) approved a large-scale clinical trialthe Targeting Aging with Metformin (TAME) trialto test its effects on biological aging (AFAR 2016)

50 years of research, 200+ papers

BPC-157 offers relief by: Protecting endothelial lining inside joints Reducing cytokine-driven inflammation in joint capsules Stimulating synovial membrane healing Applications : Shoulder impingement Meniscus irritation Cartilage thinning or wear Generalized wear-and-tear joint pain Intra-articular BPC-157 showed protective effects against cartilage degeneration and promoted joint capsule healing in models of induced arthritis. Sikiric et al., Medical Hypotheses 4

As with all applications above, these findings are confined to preclinical settings and do not establish human effects

The evidence base is thinner than the popular discourse suggests