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Apparently, metformin acts directly on gut bacteria to increase their vitamin B12 uptake, leading to increasing competition for available dietary vitamin B12 and ultimately to human vitamin B12 deficiency (55)
they then produce the cytokine IL-1 and the chemokine CCL2, which enhance OPC mobilization and the repopulation of demyelinated areas (Moyon et al., 2015)
Mary Claire Haver citing Mayo Clinic research
It modulates metabolic pathways, including pyruvate dehydrogenase activity, proteolysis, and protein synthesis, while also having anti-inflammatory and antioxidant characteristics
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