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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo
Why it matters for body composition: Smaller fat cells mean less inflammation and better insulin sensitivity, two key components for losing fat while preserving muscle
Your 2mg dose is now 4ml a very large subcutaneous injection volume that is uncomfortable and potentially problematic for absorption
Webmd.com
These issues are often the primary reason people need a consistent, long-term injection schedule
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