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Ensure adequate fluid intake and contact your GP if symptoms are severe or prolonged Changes in mood or mental health : Whilst sertraline treats depression and anxiety, any worsening of mental health symptoms, emergence of suicidal thoughts, or unusual behavioural changes should be reported immediately Appetite changes : Significant loss of appetite or difficulty eating adequate nutrition requires medical review Signs of pancreatitis : Severe abdominal pain radiating to the back, nausea, and vomiting warrant urgent medical assessment, as GLP-1 agonists carry a small risk of pancreatitis [1] [5] Gallbladder problems : Wegovy and rapid weight loss can increase the risk of gallstones and gallbladder inflammation

Heart rate changes were monitored as part of the cardiovascular safety assessment

It may also influence fibroblast activity and extracellular matrix remodeling, contributing to structural tissue repair

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The cells were washed with PBS and incubated in fresh medium for 9 h